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id="0mmock6eq" class="boxBlock"> <div id="0mmock6eq" class="elementContainer" data-appid="column" id="layout_43245251"> <div id="0mmock6eq" class="appWrapper" id="app_placeholder" data-appid="placeholder" data-state=""> <div id="0mmock6eq" class="appMask"></div> <div id="0mmock6eq" class="appContent"> <div id="0mmock6eq" class="appWrapper" id="layout_20040304" role="draggable" data-appid="panel" data-state="false"> <div class="0mmock6eq" id="layout_20040304_style" class="hide"> </div> <div id="0mmock6eq" class="appMask"></div> <div id="0mmock6eq" class="appContent"> <div id="0mmock6eq" class="phx-panel-wrap" data-showtitle="yes" data-isad="no" data-pattern="fixed" data-place="6" data-width="200" data-height="200"> <div id="0mmock6eq" class="phx-panel-title clearfix"> <span id="0mmock6eq" class="text pull-left">文章詳情</span> </div> <div id="0mmock6eq" class="phx-panel"> <div id="0mmock6eq" class="appWrapper" id="app_24330443" role="draggable" data-type="app" data-appid="datumInfo" data-config="" data-state="true"> <div id="0mmock6eq" class="appMask"></div> <div id="0mmock6eq" class="appContent"> <div id="0mmock6eq" class="datum_info"> <h1 class="title">濾泡輔助性T細(xì)胞（Tfh）</h1> <div id="0mmock6eq" class="bgcolor_01"> <div id="0mmock6eq" class="bgcolor_sum"> <div id="0mmock6eq" class="left">日期：2024-11-22 05:59</div> <div id="0mmock6eq" class="right">瀏覽次數(shù)：9796</div> </div> <div id="0mmock6eq" class="bgcolor_sum01"> 摘要：簡(jiǎn)介: 濾泡輔助性T細(xì)胞（ Follicular helper T cell， Tfh ）是由 Schaerli 和 Breifeld 在2000年發(fā)現(xiàn)的，且在2008年 King 等人確定了 Tfh 細(xì)胞是一種獨(dú)立的 CD4+ T 效應(yīng)細(xì)胞亞群。Tfh細(xì)胞直接來(lái)源于初始T細(xì)胞（ Na?ve T cells ），定位于**濾泡，主要功能是輔助B細(xì)胞增殖和產(chǎn)生抗體，參與體液**。它對(duì)**系統(tǒng)的建立以及功能的完善非常重要，特別是針對(duì)感染**的體液**起決定性調(diào)節(jié)作用，同時(shí)在自身**和腫瘤發(fā)生等相關(guān)**中也扮演重要角色。其特殊之處在于，它沒(méi)有溶解細(xì)胞或吞噬細(xì)胞的作用，但卻可以激活并指導(dǎo)其他... </div> </div> <div id="0mmock6eq" class="content"> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"><strong>簡(jiǎn)介:</strong> 濾泡輔助性T細(xì)胞（ Follicular helper T cell， Tfh ）是由 Schaerli 和 Breifeld 在2000年發(fā)現(xiàn)的，且在2008年 King 等人確定了 Tfh 細(xì)胞是一種獨(dú)立的 CD4<sup>+</sup> T 效應(yīng)細(xì)胞亞群。Tfh細(xì)胞直接來(lái)源于初始T細(xì)胞</span><span style="font-size:14px;font-family:宋體;">（ </span><span style="font-size:14px;font-family:宋體;">Na?ve T cells </span><span style="font-size:14px;font-family:宋體;">）</span><span style="font-size:14px;font-family:宋體;">，定位于**濾泡，主要功能是輔助B細(xì)胞增殖和產(chǎn)生抗體，參與體液**。它對(duì)**系統(tǒng)的建立以及功能的完善非常重要，特別是針對(duì)感染**的體液**起決定性調(diào)節(jié)作用，同時(shí)在自身**和腫瘤發(fā)生等相關(guān)**中也扮演重要角色。其特殊之處在于，它沒(méi)有溶解細(xì)胞或吞噬細(xì)胞的作用，但卻可以激活并指導(dǎo)其他**細(xì)胞。</span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"><strong>主要標(biāo)記物：</strong>Tfh 細(xì)胞屬于 CD4<sup>+</sup> T 細(xì)胞亞群，其表型特征為 CXCR5<sup>+</sup>CD40L<sup>hi</sup>ICOS<sup>hi </sup>，并且還表達(dá)細(xì)胞因子 IL-21 和轉(zhuǎn)錄因子 Bcl-6 。 IL-21 和 Bcl-6 </span><span style="font-size:14px;font-family:宋體;">（ </span><span style="font-size:14px;font-family:宋體;">B-cell lymphoma 6 </span><span style="font-size:14px;font-family:宋體;">）</span><span style="font-size:14px;font-family:宋體;">對(duì)于 Tfh 細(xì)胞的發(fā)生和發(fā)育至關(guān)重要。其中 IL-21 誘導(dǎo) Tfh 的分化并促進(jìn)其表面 CXCR5 的表達(dá)； Bcl-6 對(duì)于 Tfh 轉(zhuǎn)移到**濾泡和 B 細(xì)胞發(fā)生中心</span><span style="font-size:14px;font-family:宋體;">（ </span><span style="font-size:14px;font-family:宋體;">Germinal center </span><span style="font-size:14px;font-family:宋體;">）</span><span style="font-size:14px;font-family:宋體;">的形成必不可少。</span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-align:center;background-color:#FFFFFF;"> <img src="http://www.bio-city.net/uploads/common/image/20141230/20141230-092951_319189862.jpg" width="294" height="350" alt="" style="border-style:none;vertical-align:top;display:block;margin:0px auto;"> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-align:center;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;">圖1 Tfh 細(xì)胞主要標(biāo)記結(jié)構(gòu)示意圖</span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"><strong>功能特征：</strong></span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"><strong>1.各類因子對(duì) Tfh 細(xì)胞分化的影響</strong></span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"><strong>ICOS:</strong> Tfh 細(xì)胞上的 ICOS 與 B 細(xì)胞上的 ICOS-Ligand 作用，傳遞協(xié)同刺激信號(hào)，對(duì) Tfh 細(xì)胞的產(chǎn)生及存活、 IL-21 的表達(dá)、發(fā)生中心的形成及特異性抗體的產(chǎn)生都至關(guān)重要。 </span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"><strong>IL-6:</strong> IL-6 因子具有促炎癥和**癥雙重角色。作為**癥因子，其具有抑制 TNF-a 和 IL-1 的功能，同時(shí)激活 IL-1Ra 和 IL-10 ，且 IL-6 對(duì) Tfh 細(xì)胞的產(chǎn)生是必需的。研究顯示，如單獨(dú)缺失 IL-6 ，雖不影響發(fā)生中心的形成，但不能實(shí)現(xiàn) Tfh 細(xì)胞的分化。 </span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"><strong>IL-21: </strong>IL-21 的結(jié)構(gòu)與 IL-2、 IL-15 相似，由活化的 T 細(xì)胞表達(dá)，且可以誘導(dǎo) T 細(xì)胞和 B 細(xì)胞增殖。在沒(méi)有 TGF-beta 的情況下， IL-21 開(kāi)啟 Tfh 細(xì)胞的分化。 </span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"><strong>CXCR5:</strong> CXCR5 又稱 CD185 ，是 CXCL13 的受體。 CXCR5 只在 Tfh 細(xì)胞上持續(xù)表達(dá)， Tfh 細(xì)胞通過(guò) CXCR5 在 CXCL13 的趨化作用下募集至**濾泡發(fā)生中心</span><span style="font-size:14px;font-family:宋體;">（ </span><span style="font-size:14px;font-family:宋體;">Germinal center </span><span style="font-size:14px;font-family:宋體;">）</span><span style="font-size:14px;font-family:宋體;">。</span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-align:center;background-color:#FFFFFF;"> <img src="http://www.bio-city.net/uploads/common/image/20141230/20141230-093118_120895786.jpg" width="207" height="350" alt="" style="border-style:none;vertical-align:top;display:block;margin:0px auto;"> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-align:center;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;">圖2 各類因子與 Tfh 細(xì)胞分化的關(guān)系示意圖</span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"><strong>2.Tfh 細(xì)胞與各類**</strong></span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;">Tfh 細(xì)胞的主要作用是增加高親和力 B 細(xì)胞和長(zhǎng)壽漿細(xì)胞的形成，并幫助他們轉(zhuǎn)移到發(fā)生中心（GC）。在接受抗原刺激后，初始 B 細(xì)胞**移動(dòng)到 T 細(xì)胞區(qū)，且在來(lái)自 Tfh 細(xì)胞和抗原呈遞細(xì)胞的共刺激作用下開(kāi)始活化并形成發(fā)生中心。當(dāng)發(fā)生中心的 B 細(xì)胞開(kāi)始分化為漿細(xì)胞或記憶 B 細(xì)胞時(shí)， Bcl-6 會(huì)阻止 B 細(xì)胞的增殖，因?yàn)?Bcl-6 可以抑制 B 細(xì)胞活化基因的表達(dá)，如 CD69、 STAT1 和 CD80 等，同時(shí)也會(huì)通過(guò)調(diào)節(jié) Prdm1 來(lái)抑制發(fā)生中心的 B 細(xì)胞向漿細(xì)胞分化。 Tfh 細(xì)胞通過(guò) CD40 的作用致使 Bcl-6 轉(zhuǎn)錄沉默，從而促使發(fā)生中心 B 細(xì)胞存活和增殖。且在這一過(guò)程中，CD40L、PD-1、BAFF、IL-4 和 IL-21 等信號(hào)分子的參與也是必不可缺的。</span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-align:center;background-color:#FFFFFF;"> <img src="http://www.bio-city.net/uploads/common/image/20141230/20141230-093204_960026782.jpg" width="222" height="350" alt="" style="border-style:none;vertical-align:top;display:block;margin:0px auto;"> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-align:center;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;">圖3 Tfh 細(xì)胞主要功能示意圖</span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;">因此，基于 Tfh 細(xì)胞的功能特性，其與多種**密切相關(guān)。 Tfh 細(xì)胞及相關(guān)分子的缺陷會(huì)導(dǎo)致正常的 B 細(xì)胞反應(yīng)不能完成，產(chǎn)生體液**缺陷。相反， Tfh 功能亢進(jìn)也會(huì)導(dǎo)致病態(tài)的自身**反應(yīng)，介導(dǎo)自身**病的發(fā)生。目前對(duì) Tfh 的研究也主要集中在其與自身****和 HIV 的關(guān)系上面。</span><span style="font-size:10.5pt;font-family:宋體;"></span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-indent:21pt;text-align:justify;background-color:#FFFFFF;"> <span style="font-size:14px;font-family:宋體;"><br> </span> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 宋體;line-height:21.6px;white-space:normal;text-align:center;background-color:#FFFFFF;"> <img src="http://www.bio-city.net/uploads/common/image/20141230/20141230-094853_949742586.jpg" width="600" height="260" alt="" style="border-style:none;vertical-align:top;display:block;margin:0px auto;"> </p> <p style="margin-top:0px;margin-bottom:0px;padding:0px;font-family:'Microsoft Yahei', arial, 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